Season 21 is set topremiere in September 2024.

But in the end, they finally made it down the aisle and got married.

Long-distance relationships are hard, andmanyGreys Anatomycouplesunderstand that.

Ellen Pompeo as Meredith Grey in Grey’s Anatomy

Meredith and Derek decided to give up their perfect wedding to Izzie and Alex (Justin Chambers) instead.

The quote also made the episodes title seem even more fitting.

8"Sometimes, it’s good to be scared.

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Image via ABC Studios

It means you still have something to lose."

The moment inspired Meredith to be honest with Derek about her feelings.

Richards concerns were justified when Mark delivered these lines to Jackson (Jesse Williams) about love and fear.

GreysAnatomyWhatADifferenceADayMakesS5E22

The fact that these were among Marks final words in the show made his death all the more tragic.

6"Screw beautiful, Im brilliant.

If you want to appease me, compliment my brain."

Constance Zimmer and James Pickens Jr. in Grey’s Anatomy as Alana Cahill and Richard Webber

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It’s often cited as a fan favorite, and its remembered as one of Cristinas best moments.

Its also part of what made her such a great character whose presence on the show is still missed.

5"Don’t let what he wants eclipse what you need.

GreysAnatomyS9E2RememberTheTime

He’s very dreamy, but he’s not the sun.

She also reminded Meredith that looks arent everything.

Being aware of ones flaws is a crucial part of overcoming them, but its just the first step.

Sandra Oh in Grey’s Anatomy as Cristina Yang

Image via ABC Studios

3It doesn’t matter how tough we are, trauma always leaves a scar.

[…] Maybe going through all that is what keeps us moving forward."

In a voiceover in the episodes final moments, Alex talked about the impact of trauma.

Ellen Pompeo and Sandra Oh in Grey’s Anatomy as Meredith and Cristina

Image via ABC

NEXT:The Saddest Character Exits on ‘Grey’s Anatomy’, Ranked

Sandra Oh in Grey’s Anatomy as Cristina Yang

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Justin Chambers as Alex Karev, wearing a suit and smiling in Grey’s Anatomy

Image via ABC

Kevin McKidd and Constance Zimmer in Grey’s Anatomy as Owen Hunt and Alana Cahill

Image via ABC Studios

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