Now midway through Season 21,Grey’s Anatomyhas quite the legacy.

At its core are the characters, even as many have entered and exited theshowover the years.

These have led to a number of character development arcs,romantic relationships, and strong friendships.

Meredith and Cristina hugging in Grey’s Anatomy.

Image via ABC

These are the 10 best friendships inGrey’s Anatomy, ranked.

They seek comfort from one another, and, at times, more than just friendship.

Together they discover that neither medicine nor relationships can be defined in black and white.

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A high-intensity medical drama which follows Meredith Grey and the team of doctors at Grey Sloan Memorial, who are faced with life-or-death decisions on a daily basis. They seek comfort from one another, and, at times, more than just friendship. Together they discover that neither medicine nor relationships can be defined in black and white.

Teddy and Arizona first became friends after Arizona boldly confronted Teddy about her feelings for Owen.

Derek became Lexie’s mentor at work, but at home, he was her brother and close friend.

These two really became a great duo in Season 8.

Arizona Robbins (Jessica Capshaw) and Teddy Altman (Kim Raver) in ‘Grey’s Anatomy’

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Derek became Lexie’s mentor at work, but at home, he was her brother and close friend.

8Bailey and George

Played by Chandra Wilson and T.R.

That being said, George (T. R. Knight) was always her clear favorite.

Derek Shepherd and Lexie Grey sitting next to each other at Meredith’s house in Grey’s Anatomy Season 8.

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George’s death absolutely gutted Bailey, though, and it permanently changed her as a character.

George’s death absolutely gutted Bailey, though, and it permanently changed her as a character.

6Izzie and George

Played by Katherine Heigl and T.R.

George O’Malley helping Miranda Bailey deliver her baby in Season 2 of Grey’s Anatomy.

Image via ABC

Played by Ellen Pompeo, Justin Chambers, Et al.

That being said,Meredith and Alex’s friendship is one of the show’s best and longest-running bonds.

Meredith always understood Alex early on in the show, even when she didn’t like him…

Mark Sloan and Jackson Avery standing together at the hospital in Grey’s Anatomy Season 8.

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This meant a lot to him, and he stood by her side through everything.

He even walked her down the aisle at her wedding to Arizona.

Mark and Callie’s friendship was unconventional, asthey also became co-parentswhen she got pregnant with Sofia.

The members of the MAGIC group wearing scrubs, eating together in the cafeteria in Grey’s Anatomy Season 4.

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She was never the same characterafter Mark died, and it was heartbreaking to watch this play out.

Mark made it clear that Derek was a major factor for him in staying in Seattle.

Mark made it clear that Derek was a major factor for him in staying in Seattle.

Alex Karev (Justin Chambers) and Meredith Grey (Ellen Pompeo) sitting by the fire in Grey’s Anatomy.

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Mark and Derek were one ofGrey’s Anatomy’s most interesting friendship dynamics.

NEXT:The 12 Most Hated ‘Grey’s Anatomy’ Characters, Ranked

Mark Sloan and Derek Shepherd standing together and smiling in Grey’s Anatomy.

Image via ABC

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