The 2000s were a time of great change for cinema.

However, few people would’ve foreseen Damon’s next career path: action hero.

Doubtfire,Aladdin, andThe Birdcage.

Blended image showing Salma Hayek, Heath Ledger, and Charlize Theron

Custom Image by Federico Napoli

Williams is good inChristopher Nolan’sInsomnia, but he is absolutely brilliant in the psychological thrillerOne Hour Photo.

Thus, it was the perfect time to take some acting risks; enterCollateral.

Cruise’s villainous turn inCollateralstands as one of the finest performances of his long and esteemed career.

Sy Parrish, standing in a grocery store aisle and staring blankly into the camera in One Hour Photo

Image via Fox Searchlight

If a movie had Murphy, audiences could expect wild antics, irreverent humor, and endless energy.

In a purely villainous and despicable role,Washington is astounding and wholly believable.

It turns out King Kong, indeed, has nothing on him.

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If Hayek wanted a change in her career, she knew she had to engineer it herself.

The actress spearheaded a biopic of Mexican painter Frida Kahlo.

However, her hard work paid off.

Tom Cruise’s Vincent looking menacingly through a subway window in Collateral.

Image via Dreamworks Pictures

In 2003,Salma Hayek became the first Mexican actressto earn an Oscar nomination for Best Actress.

For her work inMonster, Theron won a mountain of accolades, including the 2004 Oscar for Best Actress.

The actress completely disappears into the role, justifying her against-jot down casting from her first scene.

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NEXT:The 10 Biggest Movie Stars of the 2000s, Ranked

Jimmy “Thunder” Early singing on stage in Dreamgirls

Image via Paramount Pictures

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Alonzo Harris looking intently in Training Day

Image via Warner Bros. Pictures

The poster for Training Day

Salma Hayek as Frida Kahlo staring at the camera while resting her chin on her hand in the film Frida.

Image via Miramax

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Charlize Theron as Aileen Wuornos aiming a gun down at someone in Monster

Image via Newmarket Films

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Mary smoking a cigar while sitting on a couch in Precious.

Image via Lionsgate

Precious Movie Poster

Marion Cotillard as Édith Piaf singing in La Vie En Rose

Image via Icon FIlm Distribution

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Joker (Heath Ledger) sits on a floor in an interrogation room with his back against a wall in The Dark Knight.

Image via Warner Bros. Pictures

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Heath Ledger

Salma Hayek

Charlize Theron